Targeted FAK activation in cardiomyocytes protects the heart from ischemia/reperfusion injury

OBJECTIVE: We previously reported that cardiac-restricted deletion of focal adhesion kinase (FAK) exacerbated myocyte death following ischemia/reperfusion (I/R). Here we interrogated whether targeted elevation of myocardial FAK activity could protect the heart from I/R injury. METHODS AND RESULTS: T...

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Udgivet i:Arterioscler Thromb Vasc Biol
Main Authors: Cheng, Zhaokang, DiMichele, Laura A., Hakim, Zeenat S., Rojas, Mauricio, Mack, Christopher P., Taylor, Joan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237311/
https://ncbi.nlm.nih.gov/pubmed/22383703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.245134
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