An eIF4E-interacting peptide induces cell death in cancer cell lines

The eukaryotic initiation factor eIF4E is essential for cap-dependent initiation of translation in eukaryotes. Abnormal regulation of eIF4E has been implicated in oncogenic transformation. We developed an eIF4E-binding peptide derived from Angel1, a partner of eIF4E that we recently identified. We s...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Masse, M, Glippa, V, Saad, H, Le Bloas, R, Gauffeny, I, Berthou, C, Czjzek, M, Cormier, P, Cosson, B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237268/
https://ncbi.nlm.nih.gov/pubmed/25356869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.457
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