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P7C3 and an unbiased approach to drug discovery for neurodegenerative diseases
A novel neuroprotective small molecule was discovered using a target-agnostic in vivo screen in living mice. This aminopropyl carbazole, named P7C3, is orally bioavailable, crosses the blood–brain barrier, and is non-toxic at doses several fold higher than the efficacious dose. The potency and drug-...
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| Pubblicato in: | Chem Soc Rev |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4237066/ https://ncbi.nlm.nih.gov/pubmed/24514864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cs60448a |
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