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Demonstration of 26-hydroxylation of C27-steroids in human skin fibroblasts, and a deficiency of this activity in cerebrotendinous xanthomatosis.

26-Hydroxylation of 5 beta-cholestane-3 alpha, 7 alpha, 12 alpha-triol and other C27-steroids was demonstrated in cultured skin fibroblasts from healthy individuals. Activities in skin fibroblasts were approximately 5-10% of those previously found in human liver homogenates, and were inhibited by CO...

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Vydáno v:J Clin Invest
Hlavní autoři: Skrede, S, Björkhem, I, Kvittingen, E A, Buchmann, M S, Lie, S O, East, C, Grundy, S
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 1986
Témata:
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423662/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3745434/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI112633
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