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A novel pathway for biosynthesis of cholestanol with 7 alpha-hydroxylated C27-steroids as intermediates, and its importance for the accumulation of cholestanol in cerebrotendinous xanthomatosis.

A mixture of 7 alpha-3H- and 4-14C-labeled cholesterol was administered intravenously to rats. Cholestanol with 20-30% lower ratio between 3H and 14C than in cholesterol could be isolated from different organs. In a healthy human control, cholestanol isolated from feces had a 3H/14C ratio which was...

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書目詳細資料
發表在:J Clin Invest
Main Authors: Skrede, S, Björkhem, I, Buchmann, M S, Hopen, G, Fausa, O
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 1985
主題:
在線閱讀:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423517/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3919058/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI111719
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