Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback loops signaling

BACKGROUND: MUC4 plays important roles in the malignant progression of human pancreatic cancer. But the huge length of MUC4 gene fragment restricts its functional and mechanism research. As one of its splice variants, MUC4/Y with coding sequence is most similar to that of the full-length MUC4 (FL-MU...

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發表在:J Transl Med
Main Authors: Zhu, Yi, Zhang, Jing-Jing, Xie, Kun-Ling, Tang, Jie, Liang, Wen-Biao, Zhu, Rong, Zhu, Yan, Wang, Bin, Tao, Jin-Qiu, Zhi, Xiao-Fei, Li, Zheng, Gao, Wen-Tao, Jiang, Kui-Rong, Miao, Yi, Xu, Ze-Kuan
格式: Artigo
語言:Inglês
出版: BioMed Central 2014
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236435/
https://ncbi.nlm.nih.gov/pubmed/25367394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0309-8
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