Specific-detection of clinical samples, systematic functional investigations, and transcriptome analysis reveals that splice variant MUC4/Y contributes to the malignant progression of pancreatic cancer by triggering malignancy-related positive feedback loops signaling

BACKGROUND: MUC4 plays important roles in the malignant progression of human pancreatic cancer. But the huge length of MUC4 gene fragment restricts its functional and mechanism research. As one of its splice variants, MUC4/Y with coding sequence is most similar to that of the full-length MUC4 (FL-MU...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Zhu, Yi, Zhang, Jing-Jing, Xie, Kun-Ling, Tang, Jie, Liang, Wen-Biao, Zhu, Rong, Zhu, Yan, Wang, Bin, Tao, Jin-Qiu, Zhi, Xiao-Fei, Li, Zheng, Gao, Wen-Tao, Jiang, Kui-Rong, Miao, Yi, Xu, Ze-Kuan
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236435/
https://ncbi.nlm.nih.gov/pubmed/25367394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0309-8
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