MDM4 Overexpressed in Acute Myeloid Leukemia Patients with Complex Karyotype and Wild-Type TP53

Acute myeloid leukemia patients with complex karyotype (CK-AML) account for approximately 10–15% of adult AML cases, and are often associated with a poor prognosis. Except for about 70% of CK-AML patients with biallelic inactivation of TP53, the leukemogenic mechanism in the nearly 30% of CK-AML pat...

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Veröffentlicht in:PLoS One
Hauptverfasser: Li, Li, Tan, Yanhong, Chen, Xiuhua, Xu, Zhifang, Yang, Siyao, Ren, Fanggang, Guo, Haixiu, Wang, Xiaojuan, Chen, Yi, Li, Guoxia, Wang, Hongwei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4236138/
https://ncbi.nlm.nih.gov/pubmed/25405759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0113088
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