MDM2 overexpression is rare in ovarian carcinoma irrespective of TP53 mutation status.

Somatic mutations in TP53 are seen in many human cancers. In addition, the protein product of the wild-type TP53 can be sequestered by the protein MDM2 (murine double minute 2). This protein is commonly overexpressed in human sarcomas and gliomas, usually as a result of gene amplification. In this s...

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Bibliografske podrobnosti
Main Authors: Foulkes, W. D., Stamp, G. W., Afzal, S., Lalani, N., McFarlane, C. P., Trowsdale, J., Campbell, I. G.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 1995
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034047/
https://ncbi.nlm.nih.gov/pubmed/7547235
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