Heterogeneity of the Abnormal Prion Protein (PrP(Sc)) of the Chandler Scrapie Strain

The pathological prion protein, PrP(Sc), displays various sizes of aggregates. In this study, we investigated the conformation, aggregation stability and proteinase K (PK)-sensitivity of small and large PrP(Sc) aggregates of mouse-adapted prion strains. We showed that small PrP(Sc) aggregates, previ...

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Publicado en:Pathogens
Main Authors: Kasai, Kazuo, Iwamaru, Yoshifumi, Masujin, Kentaro, Imamura, Morikazu, Mohri, Shirou, Yokoyama, Takashi
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235706/
https://ncbi.nlm.nih.gov/pubmed/25436883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens2010092
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