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Activation of PI3K and R-Ras Signaling Promotes the Extension of Sensory Axons on Inhibitory Chondroitin Sulfate Proteoglycans

Chondroitin sulfate proteoglycans (CSPGs) are extracellular inhibitors of axon extension and plasticity, and cause growth cones to exhibit dystrophic behaviors. Phosphoinositide 3-kinase (PI3K) is a lipid kinase activated by axon growth promoting signals. In this study we used embryonic chicken dors...

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Pubblicato in:Dev Neurobiol
Autori principali: Silver, Lee, Michael, James V., Goldfinger, Lawrence E., Gallo, Gianluca
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235675/
https://ncbi.nlm.nih.gov/pubmed/24578264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dneu.22174
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