Adiposity induces lethal cytokine storm after systemic administration of stimulatory immunotherapy regimens in aged mice

Aging is a contributing factor in cancer occurrence. We recently demonstrated that systemic immunotherapy (IT) administration in aged, but not young, mice resulted in induction of rapid and lethal cytokine storm. We found that aging was accompanied by increases in visceral fat similar to that seen i...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Mirsoian, Annie, Bouchlaka, Myriam N., Sckisel, Gail D., Chen, Mingyi, Pai, Chien-Chun Steven, Maverakis, Emanuel, Spencer, Richard G., Fishbein, Kenneth W., Siddiqui, Sana, Monjazeb, Arta M., Martin, Bronwen, Maudsley, Stuart, Hesdorffer, Charles, Ferrucci, Luigi, Longo, Dan L., Blazar, Bruce R., Wiltrout, Robert H., Taub, Dennis D., Murphy, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235633/
https://ncbi.nlm.nih.gov/pubmed/25366964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20140116
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