Out-of-sequence Signal 3 paralyzes primary CD4(+) T cell dependent immunity

Primary T cell activation involves the integration of three distinct signals delivered in sequence: 1)antigen recognition, 2)costimulation, and 3)cytokine-mediated differentiation and expansion. Strong immunostimulatory events such as immunotherapy or infection induce profound cytokine release causi...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Sckisel, Gail D., Bouchlaka, Myriam N., Monjazeb, Arta M., Crittenden, Marka, Curti, Brendan D., Wilkins, Danice E.C., Alderson, Kory A., Sungur, Can M., Ames, Erik, Mirsoian, Annie, Reddy, Abhinav, Alexander, Warren, Soulika, Athena, Blazar, Bruce R., Longo, Dan L., Wiltrout, Robert H., Murphy, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4770886/
https://ncbi.nlm.nih.gov/pubmed/26231116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.06.023
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