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Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.

Familial amyotrophic lateral sclerosis (FALS) is associated with mutations in SOD1, the gene encoding copper/zinc superoxide dismutase (CuZnSOD). However, the mechanism by which these mutations lead to amyotrophic lateral sclerosis is unknown. We report that FALS mutant SODs expressed in yeast lacki...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Rabizadeh, S, Gralla, E B, Borchelt, D R, Gwinn, R, Valentine, J S, Sisodia, S, Wong, P, Lee, M, Hahn, H, Bredesen, D E
פורמט: Artigo
שפה:Inglês
יצא לאור: 1995
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC42351/
https://ncbi.nlm.nih.gov/pubmed/7708768
תגים: הוספת תג
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