Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.

Familial amyotrophic lateral sclerosis (FALS) is associated with mutations in SOD1, the gene encoding copper/zinc superoxide dismutase (CuZnSOD). However, the mechanism by which these mutations lead to amyotrophic lateral sclerosis is unknown. We report that FALS mutant SODs expressed in yeast lacki...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rabizadeh, S, Gralla, E B, Borchelt, D R, Gwinn, R, Valentine, J S, Sisodia, S, Wong, P, Lee, M, Hahn, H, Bredesen, D E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1995
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42351/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7708768/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.7.3024
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