Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells.

Familial amyotrophic lateral sclerosis (FALS) is associated with mutations in SOD1, the gene encoding copper/zinc superoxide dismutase (CuZnSOD). However, the mechanism by which these mutations lead to amyotrophic lateral sclerosis is unknown. We report that FALS mutant SODs expressed in yeast lacki...

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Hauptverfasser: Rabizadeh, S, Gralla, E B, Borchelt, D R, Gwinn, R, Valentine, J S, Sisodia, S, Wong, P, Lee, M, Hahn, H, Bredesen, D E
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC42351/
https://ncbi.nlm.nih.gov/pubmed/7708768
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