Dendritic Cells Control Fibroblastic Reticular Network Tension and Lymph Node Expansion

Following immunogenic challenge, infiltrating and dividing lymphocytes significantly increase lymph node (LN) cellularity leading to organ expansion(1,2). Here we report that the physical elasticity of LNs is maintained in part by podoplanin (PDPN) signalling in stromal fibroblastic reticular cells...

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Publicado en:Nature
Main Authors: Acton, Sophie E., Farrugia, Aaron J., Astarita, Jillian L., Mourão-Sá, Diego, Jenkins, Robert P., Nye, Emma, Hooper, Steven, van Blijswijk, Janneke, Rogers, Neil C., Snelgrove, Kathryn J., Rosewell, Ian, Moita, Luis F., Stamp, Gordon, Turley, Shannon J., Sahai, Erik, Sousa, Caetano Reis e
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235005/
https://ncbi.nlm.nih.gov/pubmed/25341788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13814
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