Retroviral transfer of a human beta-globin/delta-globin hybrid gene linked to beta locus control region hypersensitive site 2 aimed at the gene therapy of sickle cell disease.

Human gamma-globin and delta-globin chains have been previously identified as strong inhibitors of the polymerization of hemoglobin S, in contrast to the beta-globin chain, which exerts only a moderate antisickling effect. However, gamma-globin and delta-globin are normally expressed at very low lev...

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Dettagli Bibliografici
Autori principali: Takekoshi, K J, Oh, Y H, Westerman, K W, London, I M, Leboulch, P
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1995
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC42349/
https://ncbi.nlm.nih.gov/pubmed/7708766
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