CSN6 drives carcinogenesis by positively regulating Myc stability

Cullin-RING ubiquitin ligases (CRL) are critical in ubiquitinating Myc, while COP9 signalosome (CSN) controls neddylation of Cullin in CRL. The mechanistic link between Cullin neddylation and Myc ubiquitination/degradation is unclear. Here we show that Myc is a target of the CSN subunit 6 (CSN6)–Cul...

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Publicado en:Nat Commun
Autores principales: Chen, Jian, Shin, Ji-Hyun, Zhao, Ruiying, Phan, Liem, Wang, Hua, Xue, Yuwen, Post, Sean M., Choi, Hyun-Ho, Wang, Edward, Zhou, Zhongguo, Tseng, Chieh, Gully, Christopher, Velazquez-Torres, Guermarie, Fuentes-Mattei, Enrique, Yeung, Giselle, Qiao, Yi, Chou, Ping-Chieh, Su, Chun-Hui, Hsieh, Yun-Chih, Hsu, Shih-Lan, Ohshiro, Kazufumi, Shaikenov, Tattym, Wang, Huamin, Yeung, Sai-Ching Jim, Lee, Mong-Hong
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234183/
https://ncbi.nlm.nih.gov/pubmed/25395170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6384
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