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Mice defective in p53 nuclear localization signal 1 exhibit exencephaly
p53 is a major suppressor of human malignancy. The protein levels and activity are tightly regulated in cells. Early experiments identified nuclear localization signal 1 (NLS1) as a regulator of p53 localization. We have generated mice bearing a mutation in p53(NLS1), designated p53(NLS1). Our exper...
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| Publicado en: | Transgenic Res |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234151/ https://ncbi.nlm.nih.gov/pubmed/21127973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-010-9468-4 |
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