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Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors ()
Current models hold that serum antibody titers are maintained chiefly by long-lived bone marrow (BM) plasma cells (PCs). Here we characterize the role of subpopulations of BM PCs in long-term humoral responses to T-cell dependent antigen. Surprisingly, our results indicate that 40–50% of BM PCs are...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234148/ https://ncbi.nlm.nih.gov/pubmed/25326027 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401264 |
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