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Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain
Exogenous aldehydes can cause pain in animal models, suggesting that aldehyde dehydrogenase 2 (ALDH2), which metabolizes many aldehydes, may regulate nociception. To test this hypothesis, we generated a knock-in mouse with an inactivating point mutation in ALDH2 (ALDH2*2), which is also present in h...
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| izdano v: | Sci Transl Med |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4234033/ https://ncbi.nlm.nih.gov/pubmed/25163478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3009539 |
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