DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.
DNA-dependent protein kinase (DNA-PK) is a nuclear enzyme that phosphorylates several transcription factors, but its cellular function has not been elucidated. Here I show that DNA-PK strongly inhibits promoter-directed transcription initiation by Xenopus RNA polymerase I in vitro. The repression is...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42333/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7708751/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.7.2934 |
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