DNA-dependent protein kinase specifically represses promoter-directed transcription initiation by RNA polymerase I.

DNA-dependent protein kinase (DNA-PK) is a nuclear enzyme that phosphorylates several transcription factors, but its cellular function has not been elucidated. Here I show that DNA-PK strongly inhibits promoter-directed transcription initiation by Xenopus RNA polymerase I in vitro. The repression is...

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Bibliographic Details
Main Author: Labhart, P
Format: Artigo
Language:Inglês
Published: 1995
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC42333/
https://ncbi.nlm.nih.gov/pubmed/7708751
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