Interleukin-6 amplifies glucagon secretion: coordinated control via the brain and pancreas

Inappropriate glucagon secretion contributes to hyperglycemia in inflammatory disease. Previous work implicates the proinflammatory cytokine interleukin-6 (IL-6) in glucagon secretion. IL-6-KO mice have a blunted glucagon response to lipopolysaccharide (LPS) that is restored by intravenous replaceme...

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Veröffentlicht in:Am J Physiol Endocrinol Metab
Hauptverfasser: Barnes, Tammy M., Otero, Yolanda F., Elliott, Amicia D., Locke, Alicia D., Malabanan, Carlo M., Coldren, Anastasia G., Brissova, Marcela, Piston, David W., McGuinness, Owen P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233256/
https://ncbi.nlm.nih.gov/pubmed/25205821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00343.2014
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