TGFβ Induces ‘BRCAness’ and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA Repair Genes

Transforming growth factor β (TGFβ) proteins are multitasking cytokines, whose high levels at tumor sites generally correlate with poor prognosis in human cancer patients. Previously it was reported that TGFβ downregulates the expression of ataxia telangiectasia mutated (ATM) and mutS homolog 2 (MSH...

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Vydáno v:Mol Cancer Res
Hlavní autoři: Liu, Liang, Zhou, Weiying, Cheng, Chun-Ting, Ren, Xiubao, Somlo, George, Fong, Miranda Y., Chin, Andrew R., Li, Hui, Yu, Yang, Xu, Yang, O'Connor, Sean Timothy Francis, O'Connor, Timothy R., Ann, David K., Stark, Jeremy M., Wang, Shizhen Emily
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233161/
https://ncbi.nlm.nih.gov/pubmed/25103497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0201
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