TGFβ Induces ‘BRCAness’ and Sensitivity to PARP Inhibition in Breast Cancer by Regulating DNA Repair Genes

Transforming growth factor β (TGFβ) proteins are multitasking cytokines, whose high levels at tumor sites generally correlate with poor prognosis in human cancer patients. Previously it was reported that TGFβ downregulates the expression of ataxia telangiectasia mutated (ATM) and mutS homolog 2 (MSH...

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Udgivet i:Mol Cancer Res
Main Authors: Liu, Liang, Zhou, Weiying, Cheng, Chun-Ting, Ren, Xiubao, Somlo, George, Fong, Miranda Y., Chin, Andrew R., Li, Hui, Yu, Yang, Xu, Yang, O'Connor, Sean Timothy Francis, O'Connor, Timothy R., Ann, David K., Stark, Jeremy M., Wang, Shizhen Emily
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4233161/
https://ncbi.nlm.nih.gov/pubmed/25103497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0201
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