A central role for Notch in effector CD8(+) T cell differentiation

Activated CD8(+) T cells choose between terminal effector cell (TEC) or memory precursor cell (MPC) fates. We show that Notch controls this choice. Notch promoted differentiation of immediately protective TECs and was correspondingly required for clearance of an acute influenza virus infection. Notc...

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Detalhes bibliográficos
Publicado no:Nat Immunol
Main Authors: Backer, Ronald A., Helbig, Christina, Gentek, Rebecca, Kent, Andrew, Laidlaw, Brian J., Dominguez, Claudia X., de Souza, Yevan S., van Trierum, Stella E., van Beek, Ruud, Rimmelzwaan, Guus F., ten Brinke, Anja, Willemsen, A. Marcel, van Kampen, Antoine H. C., Kaech, Susan M., Blander, J. Magarian, van Gisbergen, Klaas, Amsen, Derk
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232996/
https://ncbi.nlm.nih.gov/pubmed/25344724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3027
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