Notch controls the magnitude of T helper cell responses by promoting cellular longevity

Generation of effective immune responses requires expansion of rare antigen-specific CD4(+) T cells. The magnitude of the responding population is ultimately determined by proliferation and survival. Both processes are tightly controlled to limit responses to innocuous antigens. Sustained expansion...

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Main Authors: Helbig, Christina, Gentek, Rebecca, Backer, Ronald A., de Souza, Yevan, Derks, Ingrid A. M., Eldering, Eric, Wagner, Koen, Jankovic, Dragana, Gridley, Thomas, Moerland, Perry D., Flavell, Richard A., Amsen, Derk
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384214/
https://ncbi.nlm.nih.gov/pubmed/22615412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1206044109
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