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Crystal structure of the HGF β-chain in complex with the Sema domain of the Met receptor

The Met tyrosine kinase receptor and its ligand, hepatocyte growth factor (HGF), play important roles in normal development and in tumor growth and metastasis. HGF-dependent signaling requires proteolysis from an inactive single-chain precursor into an active α/β-heterodimer. We show that the serine...

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Detalhes bibliográficos
Main Authors: Stamos, Jennifer, Lazarus, Robert A, Yao, Xiaoyi, Kirchhofer, Daniel, Wiesmann, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC423285/
https://ncbi.nlm.nih.gov/pubmed/15167892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600243
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