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Crystal structure of the HGF β-chain in complex with the Sema domain of the Met receptor
The Met tyrosine kinase receptor and its ligand, hepatocyte growth factor (HGF), play important roles in normal development and in tumor growth and metastasis. HGF-dependent signaling requires proteolysis from an inactive single-chain precursor into an active α/β-heterodimer. We show that the serine...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC423285/ https://ncbi.nlm.nih.gov/pubmed/15167892 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600243 |
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