CD4 on CD8(+) T cells directly enhances effector function and is a target for HIV infection

Costimulation of purified CD8(+) T lymphocytes induces de novo expression of CD4, suggesting a previously unrecognized function for this molecule in the immune response. Here, we report that the CD4 molecule plays a direct role in CD8(+) T cell function by modulating expression of IFN-γ and Fas liga...

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Bibliographische Detailangaben
Hauptverfasser: Kitchen, Scott G., Jones, Nicole R., LaForge, Stuart, Whitmire, Jason K., Vu, Bien-Aimee, Galic, Zoran, Brooks, David G., Brown, Stephen J., Kitchen, Christina M. R., Zack, Jerome A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC423263/
https://ncbi.nlm.nih.gov/pubmed/15173593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401500101
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