SIRT1 activator (SRT1720) improves the follicle reserve and prolongs the ovarian lifespan of diet-induced obesity in female mice via activating SIRT1 and suppressing mTOR signaling

BACKGROUND: The prevalence of obesity is increasing worldwide and significantly affects fertility and reproduction in both men and women. Our recent study has shown that excess body fat accelerates ovarian follicle development and follicle loss in rats. The aim of the present study is to explore the...

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Detalhes bibliográficos
Publicado no:J Ovarian Res
Main Authors: Zhou, Xiao-Ling, Xu, Jin-Jie, Ni, Yan-Hong, Chen, Xiao-Chun, Zhang, Hong-Xia, Zhang, Xing-Mei, Liu, Wei-Juan, Luo, Li-Li, Fu, Yu-Cai
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232623/
https://ncbi.nlm.nih.gov/pubmed/25330910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13048-014-0097-z
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