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Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint
A compromised mitotic checkpoint, the primary mechanism for ensuring that each new cell receives one copy of every chromosome, has been implicated as a contributor to carcinogenesis. However, a checkpoint response is shown here to be essential for cell survival, including that of chromosomally insta...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC423258/ https://ncbi.nlm.nih.gov/pubmed/15159543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401142101 |
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