Interruption of KLF5 acetylation converts its function from tumor suppressor to tumor promoter in prostate cancer cells

KLF5 possesses both tumor suppressing and tumor promoting activities, though the mechanism controlling these opposing functions is unknown. In cultured non-cancerous epithelial cells, KLF5 converts from pro-proliferative to anti-proliferative activity upon TGFβ-induced acetylation, which sequentiall...

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Bibliografische gegevens
Gepubliceerd in:Int J Cancer
Hoofdauteurs: Li, Xin, Zhang, Baotong, Wu, Qiao, Ci, Xinpei, Zhao, Ranran, Zhang, Zhiqian, Xia, Siyuan, Su, Dan, Chen, Jie, Ma, Gui, Fu, Liya, Dong, Jin-Tang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232457/
https://ncbi.nlm.nih.gov/pubmed/24931571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.29028
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