KLF5 inhibits angiogenesis in PTEN-deficient prostate cancer by attenuating AKT activation and subsequent HIF1α accumulation

BACKGROUND: KLF5 is a basic transcriptional factor that regulates multiple physiopathological processes. Our recent study showed that deletion of Klf5 in mouse prostate promotes tumorigenesis initiated by the deletion of Pten. While molecular characterization of Klf5-null tumors suggested that angio...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Ci, Xinpei, Xing, Changsheng, Zhang, Baotong, Zhang, Zhiqian, Ni, Jenny Jianping, Zhou, Wei, Dong, Jin-Tang
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4417294/
https://ncbi.nlm.nih.gov/pubmed/25896712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-015-0365-6
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