A Novel Simple Assay System to Quantify the Percent HCV-RNA Levels of NS5A Y93H Mutant Strains and Y93 Wild-Type Strains Relative to the Total HCV-RNA Levels to Determine the Indication for Antiviral Therapy with NS5A Inhibitors

AIM: Oral treatment with asunaprevir and daclatasvir has been reported to yield a SVR ratio of 80% in patients with genotype 1b HCV infection, however, treatment failure has been reported, especially in patients with HCV strains showing the NS5A-Y93H mutation at baseline. An assay system to detect s...

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Foilsithe in:PLoS One
Main Authors: Uchida, Yoshihito, Kouyama, Jun-ichi, Naiki, Kayoko, Mochida, Satoshi
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2014
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232421/
https://ncbi.nlm.nih.gov/pubmed/25397971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0112647
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