Significance of NS5B Substitutions in Genotype 1b Hepatitis C Virus Evaluated by Bioinformatics Analysis

To evaluate the effects of HCV NS5B amino acid substitutions on treatment outcome in Ledipasvir (LDV)/Sofosbuvir (SOF) for Japanese patients with genotype 1b HCV infection, NS5B sequences were examined in i) seven patients experiencing virologic failure after LDV/SOF in real-world practice, ii) 109...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Uchida, Yoshihito, Nakamura, Shugo, Kouyama, Jun-Ichi, Naiki, Kayoko, Motoya, Daisuke, Sugawara, Kayoko, Inao, Mie, Imai, Yukinori, Nakayama, Nobuaki, Tomiya, Tomoaki, Hedskog, Charlotte, Brainard, Diana, Mo, Hongmei, Mochida, Satoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5995875/
https://ncbi.nlm.nih.gov/pubmed/29892096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27291-7
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