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β-Arrestin inhibits NF-κB activity by means of its interaction with the NF-κB inhibitor IκBα

In addition to their roles in desensitization and signaling of seven-membrane-spanning receptors, β-arrestins have been more recently implicated in regulating non-seven-membrane-spanning receptor pathways. By using a yeast two-hybrid screen, we identified the inhibitor of NF-κB, IκBα, as a binding p...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Witherow, D. Scott, Garrison, Tiffany Runyan, Miller, William E., Lefkowitz, Robert J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC423241/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15173580/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402851101
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