Nitrated fatty acids reverse pulmonary fibrosis by dedifferentiating myofibroblasts and promoting collagen uptake by alveolar macrophages

Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease, thought to be largely transforming growth factor β (TGFβ) driven, for which there is no effective therapy. We assessed the potential benefits in IPF of nitrated fatty acids (NFAs), which are unique endogenous agonists of peroxisome...

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Bibliographic Details
Published in:FASEB J
Main Authors: Reddy, Aravind T., Lakshmi, Sowmya P., Zhang, Yingze, Reddy, Raju C.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2014
Subjects:
Research Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232282/
https://ncbi.nlm.nih.gov/pubmed/25252739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-256263
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