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The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis
Proteins that traffic through the eukaryotic secretory pathway are commonly modified with N-linked carbohydrates. These bulky amphipathic modifications at asparagines intrinsically enhance solubility and folding energetics through carbohydrate-protein interactions. N-linked glycans can also extrinsi...
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| Pubblicato in: | Nat Chem Biol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4232232/ https://ncbi.nlm.nih.gov/pubmed/25325701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1651 |
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