Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation

BACKGROUND: Pediatric glioblastoma multiforme (GBM) is rare, and there is a single study, a seminal discovery showing association of histone H3.3 and isocitrate dehydrogenase (IDH)1 mutation with a DNA methylation signature. The present study aims to validate these findings in an independent cohort...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Jha, Prerana, Pia Patric, Irene Rosita, Shukla, Sudhanshu, Pathak, Pankaj, Pal, Jagriti, Sharma, Vikas, Thinagararanjan, Sivaarumugam, Santosh, Vani, Suri, Vaishali, Sharma, Mehar Chand, Arivazhagan, Arimappamagan, Suri, Ashish, Gupta, Deepak, Somasundaram, Kumaravel, Sarkar, Chitra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2014
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232083/
https://ncbi.nlm.nih.gov/pubmed/24997139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou113
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