Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation

BACKGROUND: Pediatric glioblastoma multiforme (GBM) is rare, and there is a single study, a seminal discovery showing association of histone H3.3 and isocitrate dehydrogenase (IDH)1 mutation with a DNA methylation signature. The present study aims to validate these findings in an independent cohort...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Neuro Oncol
Autores principales: Jha, Prerana, Pia Patric, Irene Rosita, Shukla, Sudhanshu, Pathak, Pankaj, Pal, Jagriti, Sharma, Vikas, Thinagararanjan, Sivaarumugam, Santosh, Vani, Suri, Vaishali, Sharma, Mehar Chand, Arivazhagan, Arimappamagan, Suri, Ashish, Gupta, Deepak, Somasundaram, Kumaravel, Sarkar, Chitra
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2014
Materias:
Basic and Translational Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232083/
https://ncbi.nlm.nih.gov/pubmed/24997139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou113
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares