Genome-wide methylation profiling identifies an essential role of reactive oxygen species in pediatric glioblastoma multiforme and validates a methylome specific for H3 histone family 3A with absence of G-CIMP/isocitrate dehydrogenase 1 mutation

BACKGROUND: Pediatric glioblastoma multiforme (GBM) is rare, and there is a single study, a seminal discovery showing association of histone H3.3 and isocitrate dehydrogenase (IDH)1 mutation with a DNA methylation signature. The present study aims to validate these findings in an independent cohort...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Jha, Prerana, Pia Patric, Irene Rosita, Shukla, Sudhanshu, Pathak, Pankaj, Pal, Jagriti, Sharma, Vikas, Thinagararanjan, Sivaarumugam, Santosh, Vani, Suri, Vaishali, Sharma, Mehar Chand, Arivazhagan, Arimappamagan, Suri, Ashish, Gupta, Deepak, Somasundaram, Kumaravel, Sarkar, Chitra
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232083/
https://ncbi.nlm.nih.gov/pubmed/24997139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou113
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