Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody

GPCR–G-protein complexes are one of the most important components of cell-signalling cascades. Extracellular signals are sensed by membrane-associated G-protein-coupled receptors (GPCRs) and transduced via G proteins towards intracellular effector molecules. Structural studies of these transient com...

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Bibliographic Details
Published in:Acta Crystallogr F Struct Biol Commun
Main Authors: Triest, Sarah, Wohlkönig, Alexandre, Pardon, Els, Steyaert, Jan
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2014
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231852/
https://ncbi.nlm.nih.gov/pubmed/25372817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14020962
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