Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity

Living in an oxygen-rich environment is dangerous for a cell. Reactive oxygen species can damage DNA, RNA, protein and lipids. The MutT protein in Escherichia coli removes 8-oxo-deoxyguanosine triphosphate (8-oxo-dGTP) and 8-oxo-guanosine triphosphate (8-oxo-GTP) from the nucleotide pools precluding...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Gordon, Alasdair J.E., Satory, Dominik, Wang, Mengyu, Halliday, Jennifer A., Golding, Ido, Herman, Christophe
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231768/
https://ncbi.nlm.nih.gov/pubmed/25294823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku912
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