Monoclonal Antibodies against Aβ42 Fibrils Distinguish Multiple Aggregation State Polymorphisms in Vitro and in Alzheimer Disease Brain

Amyloidogenic proteins generally form intermolecularly hydrogen-bonded β-sheet aggregates, including parallel, in-register β-sheets (recognized by antiserum OC) or antiparallel β-sheets, β-solenoids, β-barrels, and β-cylindrins (recognized by antiserum A11). Although these groups share many common p...

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Vydáno v:J Biol Chem
Hlavní autoři: Hatami, Asa, Albay, Ricardo, Monjazeb, Sanaz, Milton, Saskia, Glabe, Charles
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231689/
https://ncbi.nlm.nih.gov/pubmed/25281743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.594846
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