Exendin-4 and sitagliptin protect kidney from ischemia-reperfusion injury through suppressing oxidative stress and inflammatory reaction

BACKGROUND: This study tested the hypothesis that exendin-4 and sitagliptin can effectively protect kidney from acute ischemia-reperfusion (IR) injury. METHODS: Adult SD-rats (n = 48) equally divided into group 1 (sham control), group 2 (IR injury), group 3 [IR + sitagliptin 600 mg/kg at post-IR 1,...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Chen, Yen-Ta, Tsai, Tzu-Hsien, Yang, Chih-Chau, Sun, Cheuk-Kwan, Chang, Li-Teh, Chen, Hung-Hwa, Chang, Chia-Lo, Sung, Pei-Hsun, Zhen, Yen-Yi, Leu, Steve, Chang, Hsueh-Wen, Chen, Yung-Lung, Yip, Hon-Kan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2013
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231365/
https://ncbi.nlm.nih.gov/pubmed/24161164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-11-270
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