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Inhibitors of endocytosis prevent Wnt/Wingless signalling by reducing the level of basal β-catenin/Armadillo

A key step in the canonical Wnt signalling pathway is the inhibition of GSK3β, which results in the accumulation of nuclear β-catenin (also known as CTNNB1), and hence regulation of target genes. Evidence suggests that endocytosis is required for signalling, yet its role and the molecular understand...

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Podrobná bibliografie
Vydáno v:J Cell Sci
Hlavní autoři: Gagliardi, Maria, Hernandez, Ana, McGough, Ian J., Vincent, Jean-Paul
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231306/
https://ncbi.nlm.nih.gov/pubmed/25236598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.155424
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