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TGFb1-induced phospholamban expression alters esophageal smooth muscle cell contraction in eosinophilic esophagitis

BACKGROUND: Eosinophilic esophagitis (EoE) is a chronic antigen mediated disease characterized by esophageal eosinophilia, remodeling, and fibrosis. TGFβ1 is a central regulator of EoE remodeling and increases esophageal smooth muscle cell contraction. OBJECTIVE: In this study, we aimed to understan...

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Detalhes bibliográficos
Publicado no:J Allergy Clin Immunol
Main Authors: Beppu, Lisa Y., Anilkumar, Arjun A., Newbury, Robert O., Dohil, Ranjan, Broide, David H., Aceves, Seema S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4231011/
https://ncbi.nlm.nih.gov/pubmed/24835503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2014.04.004
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