Anti-IL-5 Therapy Reduces Mast Cells and IL-9 Cells in Pediatric Eosinophilic Esophagitis

BACKGROUND: Eosinophilic esophagitis (EoE) is a clinicopathologic entity of increasing worldwide prevalence. IL-5 is essential for eosinophil trafficking and anti-IL-5 therapy decreases esophageal eosinophilia. EoE is associated with a prominent mast cell infiltration. OBJECTIVE: We investigated whe...

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Autors principals: Otani, Iris M., Anilkumar, A. Andrew, Newbury, Robert O., Bhagat, Monica, Beppu, Lisa Y., Dohil, Ranjan, Broide, David H., Aceves, Seema S.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3699422/
https://ncbi.nlm.nih.gov/pubmed/23623266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2013.02.042
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