The Talin Head Domain Reinforces Integrin-Mediated Adhesion by Promoting Adhesion Complex Stability and Clustering

Talin serves an essential function during integrin-mediated adhesion in linking integrins to actin via the intracellular adhesion complex. In addition, the N-terminal head domain of talin regulates the affinity of integrins for their ECM-ligands, a process known as inside-out activation. We previous...

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Udgivet i:PLoS Genet
Main Authors: Ellis, Stephanie J., Lostchuck, Emily, Goult, Benjamin T., Bouaouina, Mohamed, Fairchild, Michael J., López-Ceballos, Pablo, Calderwood, David A., Tanentzapf, Guy
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4230843/
https://ncbi.nlm.nih.gov/pubmed/25393120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1004756
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